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With its effectiveness and quick results, ketamine therapy has proven to be a lifesaving treatment option for many individuals suffering from various mental health disorders. However, there are different ways of administering ketamine, such as macrodosing and microdosing. Some clients prefer to go with macrodosing, while others opt for microdosing. What is the difference between each method? What are the benefits of each method? In this blog, we’ll discuss the benefits of macrodosing vs. microdosing and help you decide which method could work better for you.

As a reminder, Safe Haven Health specializes in at-home ketamine treatment with sublingual ketamine. Sublingual ketamine is a relatively new administration method and is less invasive and more convenient than IV infusions. The Safe Haven Health team has helped several clients find relief from depression, anxiety, and other mental health conditions. Still, many wonder which protocol is better for their specific needs: macrodosing or microdosing?


Benefits of Macrodosing


Macrodosing can benefit people who want to experience the full effects of ketamine in a single session. A single, higher dose of ketamine can quickly bring you into a dissociative state, where you can explore your subconscious mind and gain valuable insight. This can help you identify and process emotional blocks and break negative patterns perpetuating mental health issues. However, the effects of a single macrodose usually wear off after a few days. Here are the benefits of macrodosing ketamine:

Quick Results: With a higher dose, macrodosing ketamine quickly relieves symptoms. You may experience positive results within hours of administration rather than waiting days or weeks to notice improvements.

Cost-Effective: Macrodosing ketamine is a more cost-effective option as it requires a few sessions to experience positive results, compared to microdosing, which would involve daily administration over an extended period.

Long-Lasting Relief: A higher dose of ketamine can provide long-lasting relief from symptoms, allowing you to enjoy life without frequent medication administration.


Benefits of Microdosing Ketamine


Microdosing takes a more gradual approach to the effects of ketamine. Microdosing with sublingual ketamine means taking a small amount of the medicine regularly, usually daily or every other day. This causes a sustained release of ketamine in your system, which can help alleviate symptoms and improve your overall mindset over time. Microdosing is generally less intense than macrodosing, which may be a better option for those sensitive to dissociative effects. Here are the benefits of daily microdosing ketamine:

Consistent Results: Microdosing provides consistent results, with gradual improvement in symptoms over the weeks. The benefits may be hard to notice initially, but it allows you to see long-term improvement over time.

Reduced Side-effects: Microdosing minimizes the risk of side-effects common with a higher dosage, such as hallucinations, disorientation, or dissociation.

Better Mood and Increased Productivity. Microdosing has been reported to improve mood and mental health performance in various activities.


Side Effects and Risks of Ketamine


Ketamine has various recorded side effects ranging from mild to severe and can pose risks to some individuals. These can include nausea, vomiting, dizziness, increased blood pressure and heart rate, anxiety, muscle weakness, hallucination, and dizziness.


Choosing the Best Method for You


There is no one-size-fits-all answer to which method is “better”. It depends on your personal goals, preferences, and the severity of your condition. Some people may prefer the more intense, introspective experience of macrodosing. Others may benefit more from the consistent relief of microdosing. Alternatively, you may find that combining both approaches is optimal for your needs. It’s essential to consult with a mental health professional and follow proper safety precautions before using any psychoactive substances. Your provider will help you decide, based on your symptoms and the benefits and risks involved, the best course to take to aid your mental wellness.



Regarding the benefits of macrodosing vs. microdosing, both have their advantages. Macrodosing provides quick, cost-effective, and long-lasting relief. In comparison, microdosing provides consistent, reduced side effects, better mood, and productivity. However, each method has its risks and side effects, and it’s essential to consult with your healthcare provider to determine the most effective and safe method to treat your symptoms. Whatever method you choose, remember that ketamine therapy can immensely help and relieve many mental health conditions. Ready to start your transformation? Schedule an appointment today.